Measuring Metabolism Across Scales
These projects focus on measuring metabolism across organelles and cells to accelerate innovative discoveries in metabolism and metabolic physiology in health and disease.
The Role of Caveolae Mediated Lipid Trafficking in Cellular Metabolism
to determine molecular details of a novel lipid trafficking pathway facilitated by caveolae from the plasma membrane to internal lipid droplets and characterize its relevance in cellular metabolism
Claudia Matthaeus
University of Potsdam
Martin Lehmann
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
Differential Sympathetic Regulation of Brown Fat Metabolism
to parse effects of activating distinct sympathetic projections to blood vessels versus thermogenic adipocytes in brown fat on local transcriptomic and lipidomic signatures and systemic energy metabolism
Lori M. Zeltser
Columbia University Irving Medical Center
Joerg Heeren
University Medical Center Hamburg-Eppendorf
Bystander Metabolic Effects of Infection Across Scales
to elucidate the source signals and spatial range of bystander metabolic effects of infection and their dynamics following antimicrobial treatment
Laura-Isobel McCall
San Diego State University
Zhibo Yang
University of Oklahoma
Sub-cellular Metabolic Compartmentalization During Oocyte Development
to investigate metabolic-cytoskeleton associations during Drosophila oocyte development to gain novel insights into the functional significance of sub-cellular metabolic organization
Zita Carvalho-Santos
Instituto de Medicina Molecular (iMM)
Jorge de-Carvalho
Instituto Gulbenkian de Ciência (IGC)
Ricardo Henriques
Instituto Gulbenkian de Ciência (IGC)
Investigating the Organelle Specific Role of s-adenosylmethionine
to understand how the role of the universal methyl-donor s-adenosylmethionine has different impacts on cellular phenotype depending on its subcellular localization
Tara TeSlaa
University of California, Los Angeles
Danielle L. Schmitt
University of California, Los Angeles
Decoding Lysosome-mitochondria Circuits in Multiscale Metabolic Regulation
to establish the governing principles underlying inter-organelle communication in regulating metabolism at the subcellular, cellular and tissue levels
Rushika M. Perera
University of California, San Francisco
David Shackelford
University of California, Los Angeles
Roberto Zoncu
University of California, Berkeley
Mechanisms of Metabolite Signaling in Tissue-Resident Macrophages
to define the functional landscape of metabolite regulation over tissue-resident macrophages during health and disease
Evanna Mills
Dana-Farber Cancer Institute
Edward Chouchani
Dana-Farber Cancer Institute
Mapping Fatty Acid Synthesis in an Entire Organism, in Space and Time
to create high-resolution spatial maps of fatty acid biosynthesis at the level of the whole adult Drosophila, in the context of homeostatic changes in temperature, diet, microbiome, and during aging
Theodore Alexandrov
European Molecular Biology Laboratory (EMBL)
Carlos Ribeiro
Champalimaud Foundation
scNeuroMET: Metabolic Reprogramming During Neurogenesis in Single Cells
to decipher metabolic transitions during neurogenesis at sub-cellular resolution in live single cells using advanced non-linear optics and to explore the contribution of transcriptional regulators
Chiara Stringari
French National Centre for Scientific Research (CNRS)
Lorena Aguilar Arnal
Universidad Nacional Autónoma de México (UNAM)
Metabolic Cell Heterogeneity In the Vertebrate Embryo
to pioneer a metabolomic–transcriptomic single-cell-resolved roadmap to the vertebrate embryo in model organisms and to identify noncanonical metabolic regulators of cell differentiation
Peter Nemes
University of Maryland, College Park
Dennis Kostka
University of Pittsburgh
Cecilia Lo
University of Pittsburgh
Towards a Holistic View of Metabolism
to uncover functions for the hundreds of enzymes in peripheral metabolism with no known function, advancing the deciphering of the entire metabolic network
Maya Schuldiner
Weizmann Institute of Science
Nicola Zamboni
ETH Zurich
Synchronous Capture of Organelle Dynamics and Analyte Concentration in vivo
to reveal heterogenous organelle form and function in vivo via optical metadevices enabling ultrafast multiscale 4D sensing of oxygen tension coupled to superresolution fluorescence microscopy
Samantha C. Lewis
University of California, Berkeley
Abdoulaye Ndao
University of California, San Diego
Facilitator Cells: Metabolic Regulators of Homeostasis
to perform fundamental, systematic analysis of facilitator cell metabolism with their effector cells, bridging knowledge gaps of the crucial cells that maintain metabolic homeostasis
Anu Suomalainen
University of Helsinki
Pekka Katajisto
University of Helsinki
Imaging Metabolic Activity in Aging at Cellular Resolution
to advance a stand-alone MALDI metabolomics and isotope-tracing pipeline that visualizes metabolic activity of specific cell types and layers, and to exemplify its utility through application to aging
Joshua Rabinowitz
Princeton University
Sarah Mitchell
Princeton University
Ben Raphael
Princeton University
Unlocking Inter-immune Metabolic Communication
to develop novel methods to study metabolic interactions between dendritic cells and T cells, with the goal of identifying metabolic tipping points that influence inflammation and host defense
Russell Jones
Van Andel Institute
Connie Krawczyk
Van Andel Institute
Transplanting Mitochondria to Study their Impact on Adipogenesis
to reveal a new paradigm by which organelle contact sites form mitochondrial subpopulations controlling the metabolic and adipogenic capacity of adipose stromal cells in health, obesity and diabetes
Bart Deplancke
Ecole Polytechnique Fédérale de Lausanne (EPFL)
Carol Robinson
University of Oxford
Robin Klemm
University of Oxford
Functional Imaging and Control of Nuclear Metabolic Enzymes
to develop optogenetic tools and metabolite biosensors that provide new insights into dynamic gene expression mechanisms controlling key cellular events, including circadian rhythm
Robert Coleman
Albert Einstein College of Medicine
Louis Hodgson
Albert Einstein College of Medicine
Vladislav Verkhusha
Albert Einstein College of Medicine
Diabetic Pregnancy, Fetal Metabolism, and Brain Development
to measure cell type specific metabolism in the developing brain and understand how maternal hyperglycemia impacts fetal brain cell fate specification
Heather Christofk
UCLA David Geffen School of Medicine
Aparna Bhaduri
UCLA David Geffen School of Medicine
Kathrin Plath
UCLA David Geffen School of Medicine