The goal of this project is to generate an integrated map of cellular diversity in the human immune system across multiple tissues and the human lifespan. It will provide a resource to study mechanisms of tissue residency and the effects of aging.
Results & Resources
A significant focus for this project was optimizing tissue processing and cell isolation techniques. With samples from seven donors across eight organs, they generated and published single-cell RNA-sequencing data, including T- and B-cell receptors. They created a complete cloud-based solution for data management, processing, and sharing and built a platform for probabilistic modeling for single-cell data. This platform includes DestVI, a convolution spatial transcriptomic tool that allows for a multi-resolution analysis that models continuous variation within cell types.
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