Sorry, marketing cookies are required to view this form.
Our Science Research
The Chan Zuckerberg Initiative produces scientific research to advance our mission to support the science and technology that will make it possible to cure, prevent or manage all diseases by the end of the century. Explore a selection of publications and preprints from across our institutes and grant partners.
Exploring the ‘Digital Age of Biology’
Unlocking Human Health With AI-powered Virtual Cells
Sorry, no posts were returned with the selected filters.
A data portal for providing standardized annotations for cryo-electron tomography
Utz Ermel, Anchi Cheng, Jun Xi Ni et al. (2024) | Nature Methods
Mechanism of DNA Entrapment by the MukBEF SMC Complex and Its Inhibition by a Viral DNA Mimic
Frank Bürmann, Bryony Clifton, Sophie Koekemoer et al. (2024) | bioRxiv
Real-Space Heterogeneous Reconstruction, Refinement, and Disentanglement of CryoEM Conformational States with HetSIREN
D. Herreros, C.P. Mata, C. Noddings et al. (2024) | bioRxiv
How to Build the Virtual Cell with Artificial Intelligence: Priorities and Opportunities
Charlotte Bunne, Yusuf Roohani, Yanay Rosen et al. (2024) | Arxiv
The Structure of Cilium Inner Junctions Revealed by Electron Cryo-Tomography
Sam Li, Jose-Jesus Fernandez, Marisa D. Ruehle et al. (2024) | bioRxiv
Isotype-aware inference of B cell clonal lineage trees from single-cell sequencing data
Leah L. Weber, Derek Reiman, Mrinmoy S. Roddur et al. (2024) | Cell Genomics
Dose-Efficient Cryo-Electron Microscopy for Thick Samples Using Tilt-Corrected Scanning Transmission Electron Microscopy, Demonstrated on Cells and Single Particles
Yue Yu, Katherine A. Spoth, Michael Colletta et al. (2024) | bioRxiv
DynaMight: estimating molecular motions with improved reconstruction from cryo-EM images
Johannes Schwab, Dari Kimanius, Alister Burt et al. (2024) | Nature Methods
Ghostbuster: A Phase Retrieval Diffraction Tomography Algorithm for Cryo-EM
Joel Yeo, Benedikt J. Daurer, Dari Kimanius et al. (2024) | Ultramicroscopy
Symbolic recording of signalling and cis-regulatory element activity to DNA
Chen, W., Choi, J., Li, X. et al. (2024) | Nature
Multidimensional Analysis of the Adult Human Heart in Health and Disease Using Hierarchical Phase-Contrast Tomography
Joseph Brunet, Andrew Cook, Claire Walsh et al. (2024) | Radiology
Insights and Impact From Five Cycles of Essential Open Source Software for Science
Kate Hertweck, Carly Strasser, Dario Taraborelli (2024)
Phage anti-CRISPR control by an RNA- and DNA-binding helix–turn–helix protein
Nils Birkholz, Kotaro Kamata, Maximilian Feussner et al. (2024) | Nature
Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus
Law, C., Wacleche, V.S., Cao, Y. et al. (2024) | Nature
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4
Femke M. Feringa, Sascha J. Koppes-den Hertog, Lian Wang et al. (2024) | bioRxiv
More Than a Phase: Uncovering the Structure of Materials with Electron Phase Retrieval Techniques
Stephanie Ribet, Georgios Varnavides, Yue Yu et al. (2024) | Microscopy and Microanalysis
Towards More Efficient Use of Electrons: Demonstrating Cryo-4D-STEM Phase Imaging Techniques on Thick and Thin Biological Specimens, from Organelles to Proteins
Yue Yu, Stephanie M Ribet, Georgios Varnavides et al. (2024) | Microscopy and Microanalysis
Single-cell analysis of human diversity in circulating immune cells
Kian Hong Kock, Le Min Tan, Kyung Yeon Han et al. (2024) | bioRxiv
T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis
Kedia, S., Ji, H., Feng, R. et al. (2024) | Nature Neuroscience
protoSpaceJAM: an open-source, customizable and web-accessible design platform for CRISPR/Cas insertional knock-in
Duo Peng, Madhuri Vangipuram, Joan Wong, Manuel D Leonetti (2024) | Nucleic Acids Research
Mantis: high-throughput 4D imaging and analysis of the molecular and physical architecture of cells
Ivan E. Ivanov, Eduardo Hirata-Miyasaki, Talon Chandler et al. (2023) | bioRxiv
Data-driven regularization lowers the size barrier of cryo-EM structure determination
Kimanius, D., Jamali, K., Wilkinson, M.E. et al. (2024) | Nature Methods
Omega - harnessing the power of large language models for bioimage analysis
Royer, L.A. (2024) | Nature Methods
Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury
Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury | Cell
Genome Sequencing for Diagnosing Rare Diseases
Monica Wojcik, Gabrielle Lemire, Eva Berger et al. (2024) | New England Journal of Medicine
Surforama: interactive exploration of volumetric data by leveraging 3D surfaces
Kevin A. Yamauchi, Lorenz Lamm, Lorenzo Gaifas et al. (2024) | bioRxiv
Recent Advances in Data Collection for Cryo-EM Methods
Anchi Cheng and Yue Yu (2024) | Current Opinion in Structural Biology
Active biointegrated living electronics for managing inflammation
Jiuyun Shi, Saehyun Kim, Pengju Li et al. (2024) | Science
DeepLabCut: the motion-tracking tool that went viral
Jyoti Madhusoodanan (2024) | Nature
The Wnt-dependent master regulator NKX1-2 controls mouse pre-implantation development
Nakagawa S, Carnevali D, Tan X et al. (2024) | Stem Cell Reports
Patient-focused drug development in primary sclerosing cholangitis: Insights on patient priorities and involvement in clinical trials
Michael Li, Ruth-Anne Pai, Rachel Gomel et al. (2024) | Hepatology Communications
Transthoracic ultrasound localization microscopy of myocardial vasculature in patients
Yan, J., Huang, B., Tonko, J. et al. (2024) | Nature Biomedical Engineering
Recognising the importance and impact of Imaging Scientists: Global guidelines for establishing career paths within core facilities
Graham Wright, Kerry Thompson, Yara Reis et al. (2024) | Journal of Microscopy
Beam-Induced Motion Mechanism and Correction for Improved Cryo-Electron Microscopy and Cryo-Electron Tomography
Shawn Zheng, Axel Brilot, Yifan Cheng and David Agard (2024) | Cryo-Electron Tomography: Structural Biology in Situ
An Image Processing Pipeline for Electron Cryo-Tomography in RELION-5
Alister Burt, Bodgan Toader, Rangana Warshamanage et al. (2024) | bioRxiv
Polarity-JaM: An Image Analysis Toolbox for Cell Polarity, Junction and Morphology Quantification
Wolfgang Giese, Jan Philipp Albrecht, Olya Oppenheim et al. (2024) | bioRxiv
AI-MARRVEL — A Knowledge-Driven AI System for Diagnosing Mendelian Disorders
Dongxue Mao, Chaozhong Liu, Linhua Wang et al. (2024) | New England Journal of Medicine
Antisense oligonucleotide therapeutic approach for Timothy syndrome
Chen, X., Birey, F., Li, MY. et al. (2024) | Nature
Confronting heterogeneity in cryogenic electron microscopy data: Innovative strategies and future perspectives with data-driven methods
Dari Kimanius and Johannes Schwab (2024) |
Molecular determinants and signaling effects of PKA RIα phase separation
Hardy JC, Pool EH, Bruystens JGH et al. (2024) | Molecular Cell
Nicheformer: a foundation model for single-cell and spatial omics
Anna C. Shaar, Alejandro Tejada-Lapuerta, Giovanni Palla et al. (2024) | bioRxiv
Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer
Wasko, U.N., Jiang, J., Dalton, T.C. et al. (2024) | Nature
Advances in 4D-STEM Phase-Contrast Imaging of Frozen-Hydrated Biological Specimens
Yue Yu, Michael Colletta, Katherine Spoth et al. (2024) | Biophysical Journal
Mis-spliced transcripts generate de novo proteins in TDP-43–related ALS/FTD
Sahba Seddighi, Yue A. Qi, Anna-Leigh Brown et al. (2024) | Science Translational Medicine
Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age
Steven Wells, Daniel Rainbow, Michael Mark et al. (2024) | bioRxiv
Poc1 Is a Basal Body Inner Junction Protein That Promotes Triplet Microtubule Integrity and Interconnections
Marisa Ruehle, Sam Li, David Agard et al. (2023) | bioRxiv
The next Decade in Structural Biology
Martin A. Walsh, Brent L. Nannenga, Tamir Gonen et al. (2023) | Structure
Expansion-assisted selective plane illumination microscopy for nanoscale imaging of centimeter-scale tissues
Adam Glaser, Jayaram Chandrashekar, Joshua Vasquez et al. (2024) | eLife
Better, Faster, Cheaper, Smarter: Advancing Cryo-EM
Bridget Carragher and Clinton Potter (2023) | Microscopy and Microanalysis
A spatially resolved single-cell genomic atlas of the adult human breast
Kumar, T., Nee, K., Wei, R. et al. (2023) | Nature
Public engagement with biomedical science: An analysis of Black, Hispanic, and General Population adults in the United States
Adina Abeles, Kishore Hari, Cory Manento et al. (2023) | bioRxiv
A Family of Novel Immune Systems Targets Early Infection of Nucleus-Forming Jumbo Phages
Yuping Li, Jingwen Guan, Surabhi Hareendranath et al. (2022) | bioRxiv