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HTSJDK: Enhancing the Java Toolkit for Emerging Sequencing Technologies

Project HTSJDK
Funding Cycle 2

Proposal Summary

To enhance the HTSJDK Java toolkit for genomics with an extensible plugin framework that will enable support for emerging technologies required by contemporary analysis methods, such as long reads, graph/circular references, and epigenetic modifications.

Project

HTSJDK

HTSJDK is one of two reference implementations required by the GA4GH organization (ga4gh.org) of the core genomics file formats it maintains. These formats, such as BAM and VCF, are ubiquitous within the genomics community, and HTSJDK serves as the foundation for numerous gold standard genomics software tools, including GATK (gatk.broadinstitute.org), Picard, and IGV. These tools have been used by some of the most influential and widely-cited life sciences projects to date, including The 1000 Genomes Project, The Cancer Genome Atlas, and The Framingham Heart Study.

Key Personnel

Eric Banks

Affiliation

Broad Institute of MIT and Harvard

GitHub Handle

eitanbanks
Louis Bergelson

Affiliation

Broad Institute of MIT and Harvard

GitHub Handle

lbergelson
Christopher Norman

Affiliation

Broad Institute of MIT and Harvard

GitHub Handle

cmnbroad

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