Leading a New Era of AI-Powered Biology

At our biomedical research organization, Biohub, we’re building the technology to help scientists around the world use AI-powered biology to study how cells operate, organize, and work as part of systems to understand why disease happens and how to correct it.

A zebrafish embryo glowing in blue, showing early developmental structures and cellular detail against a black background.

A zebrafish embryo captured with a light sheet microscope as it develops.

A zebrafish embryo captured with a light sheet microscope as it develops.

Frontier AI. Frontier Biology.

With unprecedented scale of compute, AI research and engineering, and state-of-the-art technology for measuring, imaging, and programming biology, Biohub is leading the first large-scale scientific initiative to push the frontier of artificial intelligence for biology.

Explore Our Virtual Cell Platform

“If we can create new tools that help scientists work faster, think in new ways, and see the world differently, it changes how we approach solving problems and what we believe is possible.”

Priscilla Chan, CZI Co-Founder and Co-CEO.

Priscilla Chan

Co-founder and Co-CEO

CZI is composed of four funding entities: the Chan Zuckerberg Initiative, LLC ; the Chan Zuckerberg Initiative Foundation (a 501(c)(3) private foundation); the Chan Zuckerberg Initiative Donor-Advised Fund (DAF) at the Silicon Valley Community Foundation; and Chan Zuckerberg Initiative Advocacy, (a 501(c)(4) organization).

News & Stories

Interested in learning more about our work in science? Get the latest information from the links below.

Four-panel collage showing Shana Kelley holding a small lab device, a colorful scientific visualization, a scientist writing on a glass board, and a close-up of laboratory equipment.

10-Year Anniversary

Celebrating 10 Years of Big Bets and Big Breakthroughs

Digital illustration of a glowing DNA double helix on the right, with blue data bars and binary patterns on the left, symbolizing biological data.

Science & Technology

4 Keys To Unlocking High-Impact Biological Insights With AI

Snippet of an abstract illustration of data flowing through a benchmarking system. Circles and diamonds represent biological inputs feeding into a central hub with flowchart symbols.

Science & Technology

Accelerating AI in Biology With Community-Driven Benchmarks

Green translucent human body silhouette with connecting lines to three medical condition categories: cardiac disease, chronic autoimmunity, and acute inflammation on black background.

Science

4 Ways Protein Monitoring Could Change the Way We Stay Healthy

A large group of people stands outdoors under tall trees, smiling and waving at the camera.

Science

Neurodegeneration Challenge Network Impact Report

Glowing blue human brain connected through neural network and flow chat to biological cell with visible internal structures, on a dark background.

Science & Technology

Reasoning With Cells

A zebrafish embryo glowing in blue, showing early developmental structures and cellular detail against a black background.

Science

Our Future in Imaging Comes Into Focus

Molecular model showing clustered proteins extending from a membrane, with Y-shaped and globular structures interacting below it.

Science & Technology

Teaching AI To Think Like a Cell

Stylized network diagram with interconnected nodes in red, orange, and yellow, representing gene relationships and illustrating CZI’s GREmLN AI model.

Science & Technology

New AI Model Could Help Scientists Pinpoint Signs of Cancer Cells

3D illustration of a CRISPR-Cas9 protein (green) bound to DNA strands (blue and yellow) on a light blue background.

Science

New Center To Advance Cures for Genetic Diseases

Shana Kelley speaks on stage at the 2025 AI+ Expo, gesturing with both hands in front of a purple background.

Science & Technology

Accelerating Discovery With AI and Biotechnology

Digital illustration of a glowing blue capsule split in half, releasing circuits and particles, symbolizing the fusion of AI and drug discovery.

Science & Technology

GEN Highlights CZI Virtual Cell Efforts

Priscilla Chan sits in a chair and gestures with her hands. She wears a black and red checkered skirt and a white T-shirt.

Science & Technology

Why We're Going All In on Biology and AI

A portion of a scatterplot of 800,000 human organoid cells forming color-coded tissue clusters, visualized in CZI’s CELLxGENE tool.

Science & Technology

CZI’s AI and Data Generation Work Mentioned in GEN and STAT

Katie Palmer, Gita Mahmoudabadi, and Patricia Brennan speak on stage at the 2025 STAT Breakthrough Summit West, seated in front of a large blue screen.

Science & Technology

CZI @ STAT Breakthrough Summit: Virtual Cells Might Be Closer Than We Think

Shows human macrophages with blue, green, and magenta markers.

Science & Technology

CZI Sets 4 Scientific Grand Challenges To Transform Human Health

Side-by-side headshots of Sara Simmonds, CZI staff computational biologist, and James Pearce, staff AI/machine learning research scientist.

Science & Technology

AI Has Entered the Biology Chat

A branching tree diagram showing evolutionary relationships among species. Each species is represented with a label and image, and color-coded paths connect them to show lineage.

Science & Technology

TranscriptFormer: A Generative Cross-Species Cell Atlas

Sandy Schmid and Marc Malandro speak on stage at a Biocom California Converge event, seated with a flower arrangement between them.

Science & Technology

Marc Malandro and Sandy Schmid on Driving the Future of Science

Priscilla Chan and Emily Chang speak on stage at SXSW. Priscilla gestures while talking, wearing a striped dress, and Emily smiles beside her, wearing a white top and pink pleated skirt.

Science & Technology

New Tools To Understand Human Health

Fluorescent microscopy image showing cell structures with highlighted organelles in green, magenta, and orange.

Science & Technology

Biohub To Develop Breakthrough Imaging Tech

Steve Quake, Eric Topol and Charlotte Bunne talk on a Zoom call.

Science & Technology

AI-Powered Virtual Cells: ‘The Holy Grail of Biology’

Science & Technology

Priscilla Chan on AI-Powered Virtual Cells at SXSW

An illustration of a researcher looking at a computer screen displaying research articles, with a world map and connected nodes symbolizing global scientific collaboration.

Science

Q&A: Scott Fraser on openRxiv Launch

A computer screen displays code on the left-hand side and a model of a UMAP on the right.

Science

Chan Zuckerberg Initiative Launches Billion Cells Project

Priscilla Chan engaging in a discussion with Patricia Brennan and Shana Kelley at a table, against a blue background.

Science & Technology

Priscilla Chan Discusses CZI’s Scientific Milestones

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