Short Wavelength Infrared 2-Photon Microscopy for Deep Tissue Imaging

Fluorescence imaging has enabled many scientific advances in biology. Yet this technology remains limited in its ability to probe biological systems at greater depths because of light absorption and scattering, due to the way biological samples interact with visible light.

To address this challenge, this project will enable researchers to achieve imaging at cellular resolution and several millimeters deep in some of the most challenging biological tissues—including brain and plant tissues. The project will develop new near-infrared emitters and new, dual infrared 2-photon microscopy methods to enable all-infrared microscopy for deep tissue biological imaging.