Analysis of Neuro-Specific Splice and 3’UTR Isoforms

Award Collaborative Pairs Pilot Project Awards (Cycle 2) (Phase 1)

Focus Area Fundamental Neuroscience

Project Description

to apply RNA-based CRISPR genomics in hESC-derived neurons for systematic functional analysis of neural-specific splicing and 3’UTR isoforms that are relevant to development and neurodegeneration.

Investigators

Eric Lai, PhD

Memorial Sloan Kettering Cancer Center

Neville Sanjana, PhD

New York Genome Center and New York University