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Functional Genomics of Neural Excitability in Prion Disease

Award Collaborative Pairs Pilot Project Awards (Cycle 2) (Phase 1)
Focus Area Neurodegeneration

Project Description

to uncover the role of G-protein-coupled receptors in prion disease pathophysiology using high-throughput functional CRISPR assays integrated with spike-resolution optical readout of neuronal activity.

Investigators

Adriano Aguzzi, MD
Adriano Aguzzi, MD

University of Zurich

Madhuvanthi Kannan, PhD
Madhuvanthi Kannan, PhD

University of Minnesota

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