Functional Genomics of Neural Excitability in Prion Disease

Award Collaborative Pairs Pilot Project Awards (Cycle 2) (Phase 1)

Focus Area Neurodegeneration

Project Description

to uncover the role of G-protein-coupled receptors in prion disease pathophysiology using high-throughput functional CRISPR assays integrated with spike-resolution optical readout of neuronal activity.

Investigators

Adriano Aguzzi, MD

University of Zurich

Madhuvanthi Kannan, PhD

University of Minnesota