High-Throughput “3D” Profiling of Single T-cells in Neurodegenerative Diseases

While immune cells have been implicated in pathogenesis of neurodegenerative diseases, we know relatively little about T-cell composition, their antigen specificity or functional status in these disorders. Dr. Jiang will leverage systems immunology tools that her lab developed to profile single T-cells that infiltrate into the brain during neurodegeneration. These experiments will be informative for understanding the role of the immune system in neurodegeneration and for developing immune-based detection and treatment approaches.