Membrane Damage and Repair in Neurodegeneration

We know relatively little about how membrane damage and repair contribute to neurodegeneration pathology or resilience. Genetic data have implicated a group of proteins involved in repair of cellular membranes, such as plasma or organelle membranes, but the cellular mechanisms underlying these associations are not clear. This project will test the novel hypothesis that membrane repair pathways are critical in a variety of neurodegenerative conditions, providing insight into if these pathways could be novel neuroprotective factors and lead to new therapeutic interventions.

This project was selected for the second phase of the Collaborative Pairs RFA.