Pooled Mapping of Neuronal Proteome Localization

Award Collaborative Pairs Pilot Project Awards (Cycle 2) (Phase 1)

Focus Area Fundamental Neuroscience

Project Description

to use a novel pooled gene tagging approach with high throughput microscopy and optical sequencing to map subcellular localization of hundreds of endogenous proteins in disease iPSC-derived neurons.

Investigators

Ophir Shalem, PhD

Children’s Hospital of Philadelphia, University of Pennsylvania

Pablo Gonzalez Camara, PhD

University of Pennsylvania