Sep 10, 2021 · 2 min read

Finding Hope in Tragedy, Married Scientists Team Up To Battle Brain Disease

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From Parkinson’s to Alzheimer’s, neurodegenerative diseases are on the rise — yet few therapies exist to combat them. That’s why the Science in Society  <https://chanzuckerberg.com/science/programs-resources/science-society/> program at CZI’s Science in Society  <https://chanzuckerberg.com/science/programs-resources/science-society/> (NDCN) is bringing together scientists to explore new ideas and new approaches.

Meet science power couple Soyon Hong and Tim Bartels: two researchers at the UK Dementia Research Institute at UCL who have found hope in the midst of personal tragedy by combining their scientific expertise in a new project supported by the Science in Society  <https://chanzuckerberg.com/science/programs-resources/science-society/>.

Learn more about how the Science in Society  <https://chanzuckerberg.com/science/programs-resources/science-society/> in order to accelerate the science of neurodegeneration — and ultimately, the path to treatments.

A women wears a wedding dress and smiles while dancing with her father. Colorful illustrations are behind them.

Losing my dad to Alzheimer’s disease was heartbreaking. But I have hope for the future, hope that society will one day be able to detect and treat brain diseases early.

Two scientists work at a lab table and look at samples through a microscope.

I am a scientist. So is my husband. We’re working together on a Science in Society  <https://chanzuckerberg.com/science/programs-resources/science-society/> to neurodegeneration.

Two people and their toddler eat at a table. The table is an illustration.

Our research starts with a question we’ve discussed for a long time at the dinner table: Does brain health begin in the gut?

Two x-ray images of the brain on a colorful background.

The brain and the gut are connected by nerve cells (called the enteric nervous system). This gut-brain axis is a hot topic in research because it could be a conduit for disease.

A man smiles and is shown in a Polaroid picture labeled "Tim Bartels."

Tim studies a protein known to build up in the gut during Parkinson’s disease before any signs of illness appear. Known as alpha-synuclein, this protein later forms clumps in the brain during the disease.

I look at how nerve cells are protected by immune cells called tissue-resident macrophages. Are these cells failing during disease? Could this cause protein to build up and spread?

Two parents kneels and pose with their two children. Everyone smiles and illustrations of marathon runners are in the background.

The two of us have worked on lots of projects together over the years — from that half-marathon we ran early in our relationship to our two kids.

A women in a wedding dress, groom and the women's father smile. Two laughing children are shown in the foreground.

But this is the first scientific collaboration between our two labs. You might say it’s the perfect marriage of our expertise!

Enjoy this story? Read about Science in Society  <https://chanzuckerberg.com/science/programs-resources/science-society/> who have teamed up to study, treat and prevent rare pediatric diseases.

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