Open Science

Our vision with CZI’s Open Science program is the universal and immediate open sharing of all scientific knowledge, processes, and outputs. Over the next 10 years, we aim to support a diverse scientific community working in the open to accelerate our understanding of human health and disease. We invest in tools, platforms, and organizations that help expand participation and access to the scientific process by making it open and reproducible, and helping scientists build on each others’ work.

The Open Science program has funded multiple initiatives through targeted grants ($46.6M) as well as the Essential Open Source Software for Science RFA ($51.8M, with Kavli Foundation and Wellcome Trust).

Grantees collaborate during a working session at the CZI Essential Open Source Software for Science meeting (CZI Open Science).
Grantees collaborate during a working session at the CZI Essential Open Source Software for Science meeting. Photo by Scott Murphy, CZI.
Grantees collaborate during a working session at the CZI Essential Open Source Software for Science meeting. Photo by Scott Murphy, CZI.
Our Approach

Tools & Resources for Research

We fund open source tools and technology that support the computational and reproducibility needs of biomedical researchers. We support the maintainers and creators of these tools and efforts to increase diversity and inclusion in their ranks.

Education & Capacity Building

We support work that increases awareness about the benefits of open science and ensures researchers are trained to effectively engage in open science practices and computational reproducibility.

Metrics & Incentives

We support projects that help shift incentives toward rewarding open science practices in biomedical research.

Sharing Platforms

We support platforms that provide mechanisms for accessing and sharing research processes and open outputs easily, and as early as possible in the research cycle.

Improved Infrastructure Technology & Integration

We support improvements to existing infrastructure, interoperability, standardization, and accessibility among systems used by scientists and research contributors.

Meet Our Grantees

Our work aims to accelerate the pace of scientific progress. Part of that is making sure researchers have access to reliable information and sustainable open source infrastructure. We support platforms where researchers can quickly and openly disseminate methods, tools, preprints (scientific papers published prior to peer review), and other research outputs. We also partner with organizations contributing to the infrastructure underlying open science and serving the needs of communities around the world.

CZI’s Essential Open Source Software for Science program supports software maintenance, growth, development, and community engagement. Graphic by CZI.
CZI’s Essential Open Source Software for Science program supports software maintenance, growth, development, and community engagement. Graphic by CZI.

Essential Open Source Software for Science

Open source software is crucial to modern scientific research, advancing biology and medicine while providing reproducibility and transparency. Yet even the most widely-used research software often lacks dedicated funding. CZI’s Essential Open Source Software for Science program supports software maintenance, growth, development, and community engagement for critical open source tools.

Open Science Team

Advisory Board

Chonnettia Jones, Michael Smith Foundation for Health Research (Advisory Board, CZI Open Science).
Chonnettia Jones Michael Smith Foundation for Health Research
Molly Maleckar, Simula Research Laboratory (Advisory Board, CZI Open Science).
Molly Maleckar Simula Research Laboratory
Emily Sena, University of Edinburgh (Advisory Board, CZI Open Science).
Emily Sena University of Edinburgh
Andrew Su, Scripps Research (Advisory Board, CZI Open Science).
Andrew Su Scripps Research
Carol Willing, Python (Advisory Board, CZI Open Science).
Carol Willing Python
Casey Greene, University of Colorado School of Medicine
Casey Greene University of Colorado School of Medicine
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