Imaging
To cure, prevent, and manage all diseases by the end of the century, we need a much deeper understanding of biological systems. Existing imaging tools provide a limited view, tending to focus on a specific biological scale without the necessary context. Researchers struggle to handle large volumes of data and to make quantitative insights, and substantial access and training gaps remain.
CZI’s imaging program aims to drive the development of:
- A suite of new imaging tools capable of observing biological processes across spatial scales at the level of tissues, cells, and proteins; and
- Robust frameworks to quantify, analyze, and share imaging data and share methods and tools.
Scientific imaging research and technology will play a critical role in enabling a deeper mechanistic understanding of health and disease, driving diagnostics, and informing directed treatments.
The Imaging program has funded the following RFAs:
- Cryo-CLEM Labels, $1.5 million
- Deep Tissue Imaging (Phase 1, $13 million and Phase 2, $19.6 million)
- Advancing Imaging Through Collaborative Projects, $5 million
- Dynamic Imaging, $19.9 million
- Napari Plugin Grants (Cycle 1, $1 million and Cycle 2, $875,000)
- Expanding Global Access to Bioimaging, $4.2 million
- Visual Proteomics Imaging, $27.5 million
- Imaging Scientists (Cycle 1, $17.8 million and Cycle 2, $10.2 million)
Chan Zuckerberg Institute for Advanced Biological Imaging
Tools: napari
CZI collaborates with napari — a community-built, Python-based, open source tool designed for browsing, annotating, and analyzing large multi-dimensional images. The napari hub is a CZI project, built and managed to support the napari community. This tool allows users to find community-built plugins that solve their analysis needs.
napari
ImagingA community-built, Python-based, open-source tool for browsing, annotating and analyzing large multi-dimensional images.
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“We want napari to help not just Python practitioners, but also biologists and other scientists who want to access Python's enormous scientific ecosystem.”
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- Super-resolution light microscopy allows scientists to view the details of subcellular organelles — units in cells with specialized functions — in living cells. Photo provided by Aaron Taylor, University of Michigan, BRCF Microscopy Core.
- A two-day-old zebrafish heart viewed through a microscope. The heart muscle membrane is shown in blue and its nuclei in red. Photo provided by CZI imaging scientist Michael Weber of the Morgridge Institute for Research, in affiliation with the University of Wisconsin-Madison.
- A forest of nerve cells (axons, dendrites, and dendritic spines of neurons) in the brain. Photo by Gao, Asano, Upadhyayula et al, Science 2019.
- These nuclear proteins (histones) in a living roundworm embryo were imaged using a dual-view inverted selective plane illumination microscopy (diSPIM). Maximum intensity projection images are rendered in different colors for visualization. Photo provided by Abhishek Kumar, Marine Biological Laboratory, Eugene Bell Center for Regenerative Biology and Tissue Engineering.
- The carotid artery of a mouse with atherosclerosis. Red, yellow, and green immune cells take up cholesterol and help regulate inflammation in the arterial wall (blue). Photo by Sara McArdle, La Jolla Institute for Immunology, LJI Microscopy Core.
- A zebrafish embryo at one day old, imaged in the Tissue Microscopy Laboratory at Texas A&M University. Photo provided by Holly Gibbs, Texas A&M University, Microscopy and Imaging Center.
Frontiers of Imaging
What if researchers could view how drugs alter the behavior of cancer cells and invade immune cells deep in the body? Or visualize how viral or bacterial pathogens hijack normal cellular functions to reproduce themselves? Such insights would open up new avenues for developing treatments and cures for many diseases.
Although there have been significant advances in biomedical imaging, we are far from the ultimate goal: to observe cells and subcellular processes in living organisms and in a minimally invasive manner. CZI’s Frontiers of Imaging effort aims to accelerate the development of disruptive imaging technologies that connect biological scales—such as proteins to cells and cells to organisms. This will allow researchers to directly visualize biological processes at the necessary resolution and in context to obtain a mechanistic understanding of health and disease.
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Interested in learning more about our work in imaging? Get the latest information from the links below.
Imaging Team
Advisory Board
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