Single-Cell Biology

Single-cell biology is the application of technologies that enable multi-omics investigation at the level of the building block of life — a single cell. By accelerating the development and application of single-cell tools and technologies, we can better understand how disease manifests in the body’s cells and tissues.

Single-cell biology is relevant to all cells in all tissues, and the field is generating data at a nearly unprecedented rate. Developing new analytical methods can help the scientific community store, analyze, and explore these rich data types.

In this image taken by a microscope, cells displayed in green, pink, and purple colors show the maze-like outline of the first part of the small intestine, called the duodenum.
An immunofluorescence image of the first part of the small intestine, called the duodenum. Photo provided by Emma Lundberg, KTH Royal Institute of Technology, Sweden.

CZI Single-Cell Biology Tools

We develop tools with and for the scientific community so that every scientist can be a better scientist. Learn about several of our single-cell tools that help diverse researchers analyze complex data and more quickly surface insights into health and disease.

CZI’s Support for the Human Cell Atlas

How can we cure, prevent, or manage all diseases? The Human Cell Atlas (HCA) is a global, scientist-led collaboration to map and characterize all cells in the healthy human body as a resource for scientific studies of health and disease. We contribute to the HCA in several ways, including supporting development of a data coordination platform, building computational tools, and grantmaking that enables methods development and data generation. Learn more about the Human Cell Atlas.

A line of cells outlined in pink and blue cuts diagonally across a black space flecked with white, displaying the one-cell thick lining of the gut.
New technology lets scientists peer inside living fruit flies, allowing them to watch immune cells and gut microbes interact across the gut's fragile, one-cell thick lining. Photo provided by Lucy Erin O'Brien, Stanford University.


Inflammation is a natural defense that helps our bodies maintain a healthy state, but chronic inflammation results in harmful diseases like asthma, arthritis, and heart disease. We fund scientists to study the role of inflammation in maintaining health and triggering diseases so that we can better diagnose, treat, and manage them.

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