Single-Cell Biology
Single-cell biology is the application of technologies that enable multi-omics investigation at the level of the building block of life, a single cell. By accelerating the development and application of single-cell tools and technologies, we can better understand how disease manifests in the body’s cells and tissues.
Single-cell biology is relevant to all cells in all tissues, and the field is generating data at a nearly unprecedented rate. Developing new analytical methods can help the scientific community store, analyze, and explore these rich data types.

The single-cell biology program has funded the following RFAs:
- Measuring Metabolism Across Scales
- Single-Cell Biology Data Insights (Cycle 1, $5.2 million and Cycle 2, $4.9 million)
- Patient-Partnered Single-Cell Analysis of Rare Pediatric Disease, $10 million
- Ancestry Networks for the Human Cell Atlas, $27.9 million
- Pediatric Networks for the Human Cell Atlas, $34.2 million
- Single-Cell Analysis of Inflammation, $14 million
- Seed Networks for the Human Cell Atlas, $67.7 million
- Collaborative Computational Tools for a Human Cell Atlas, $14.8 million
- Pilot Projects for a Human Cell Atlas, $14.9 million
CZ CELLxGENE
Built by our science technology team, Chan Zuckerberg CELL by GENE (CZ CELLxGENE) is an open source tool that allows scientists to explore and visualize high-dimensional single-cell datasets to more quickly surface important information that could lead to discoveries in treating disease. It also comprises the largest corpus of standardized single-cell datasets. Learn more at czcellxgene.org.
CZI’s Support for the Human Cell Atlas
How can we cure, prevent, or manage all diseases? The Human Cell Atlas (HCA) is a global, scientist-led collaboration to map and characterize all cells in the healthy human body as a resource for scientific studies of health and disease. We contribute to the HCA in several ways, including supporting development of a data coordination platform, building computational tools, and grantmaking that enables methods development and data generation. Learn more about the Human Cell Atlas.

Inflammation
Inflammation is a natural defense that helps our bodies maintain a healthy state, but chronic inflammation results in harmful diseases like asthma, arthritis, and heart disease. We fund scientists to study the role of inflammation in maintaining health and triggering diseases so that we can better diagnose, treat, and manage them.

Learn About Our Grantees
Funding Opportunities
News & Stories
Interested in learning more about our work in single-cell biology? Get the latest information from the links below.
To contact the Single-Cell Biology team, please complete this form.
Thank you for contacting the Single-Cell Biology team!
Your email has been sent.
An error occurred contacting the Single-Cell Biology team.
Please try again.

Join Our Science Mailing List
Be the first to know about new funding opportunities.

Join Our Team
Explore our job openings.

Explore Our Grant Resources
Read our Request for Applications.