Neurodegeneration Challenge Network

CZI’s Neurodegeneration Challenge Network brings together experimental scientists from diverse research fields, along with computational biologists and physicians, to understand the fundamental biology of neurodegenerative diseases and develop new strategies for treatment and prevention.

Two large, green, star-shaped cells appear with tree-like tendrils against a dark background.
A 3D illustration of astrocytes, star-shaped glial cells in the brain that connect neuronal cells to blood vessels.
A 3D illustration of astrocytes, star-shaped glial cells in the brain that connect neuronal cells to blood vessels.

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Showing 56 results

3D Genome Misfolding due to Repeat Instability in Neurodegenerative Disease
Investigators

Kristen Brennand - Icahn School of Medicine at Mount Sinai

Jennifer Phillips-Cremins - University of Pennsylvania

Award Collaborative Pairs Pilot Project Awards (2020)
Disease Huntington’s Disease
A Plant Small-Molecule Discovery Platform to Study Neurodegeneration
Investigators

Ankur Jain - Whitehead Institute for Biomedical Research

Jing-Ke Weng - Whitehead Institute for Biomedical Research

Award Collaborative Pairs Pilot Project Awards (2020)
Disease General Neurodegeneration
Applying Optical Pooled Screens to Identify New Therapeutic Targets
Investigators

Paul C. Blainey - The Broad Institute of MIT and Harvard

Clotilde Lagier-Tourenne - Massachusetts General Hospital

Award Collaborative Pairs Pilot Project Awards (2020)
Disease ALS
Assembling Human Cellular Models to Study Neurodegeneration
Investigators

Sergiu Pasca, MD, PhD - Stanford University

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease General Neurodegeneration
Bacterial and Toxin Engineering to Treat Motor Neuron Degeneration
Investigators

Isaac Chiu, PhD - Harvard Medical School

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease ALS, FTD
Bridging the Translational Gap: A Novel Adult Human Brain Tissue System
Investigators

Henner Koch - RWTH Aachen University

Deborah Kronenberg-Versteeg - Hertie Institute for Clinical Brain Research, University of Tuebingen

Award Collaborative Pairs Pilot Project Awards (2020)
Disease Alzheimer’s Disease
Computational Discovery to Accelerate Neurodegenerative Disease Research
Investigators

Debora Marks, PhD - Harvard University

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease General Neurodegeneration
Creating and Deploying a Toolkit for Human Microglia in Neurodegeneration
Investigators

Philip L. De Jager, MD, PhD - Columbia University (Lead and Clinical PI)

Elizabeth Bradshaw, PhD - Columbia University

Vilas Menon, PhD - Columbia University

Vladislav Petyuk, PhD - Pacific Northwest National Laboratory

Award Collaborative Science Awards (2019-2021)
Disease Alzheimer’s Disease, General Neurodegeneration
Deciphering the Mechanisms of RNA-Mediated Toxicity in Neurodegeneration
Investigators

Mitchell Guttman, PhD - California Institute of Technology

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease ALS, FTD
Decoding the Systems Pharmacology of Proteinopathy in Human Cells
Investigators

Michael Keiser, PhD - University of California, San Francisco

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease General Neurodegeneration
Elucidating Cellular Mechanisms of Neurodegeneration by Functional Genomics
Investigators

Martin Kampmann, PhD - University of California, San Francisco

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease General Neurodegeneration
Gridlock in the Nervous System: Altered RNA Localization and Local Translation in Neurodegeneration
Investigators

Eric Wang, PhD - University of Florida

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease ALS, FTD, Huntington’s Disease
Gut Macrophages and LRRK2: A Novel Paradigm for Parkinson’s Disease
Investigators

Tim Bartels - University College London and UK Dementia Research Institute

Soyon Hong - University College London and UK Dementia Research Institute

Award Collaborative Pairs Pilot Project Awards (2020)
Disease Parkinson’s Disease
High-Throughput “3D” Profiling of Single T-cells in Neurodegenerative Diseases
Investigators

Ning (Jenny) Jiang, PhD - The University of Texas at Austin

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease General Neurodegeneration
Homeostatic Neuroprotection in ALS
Investigators

Graeme Davis - University of California, San Francisco

Kira Poskanzer - University of California, San Francisco

Award Collaborative Pairs Pilot Project Awards (2020)
Disease ALS, FTD, General Neurodegeneration
Human Cell-Based Models for Bridging the Gap Between Genetics and Pathology
Investigators

William Seeley, MD, PhD - University of California, San Francisco (Lead and Clinical PI)

Steven Altschuler, PhD - University of California, San Francisco

Aimee Kao, MD, PhD - University of California, San Francisco

Lani Wu, PhD - University of California, San Francisco

Award Collaborative Science Awards (2019-2021)
Disease ALS, General Neurodegeneration
Identifying Novel Neurodegenerative Pathways in Rare Pediatric Disorders
Investigators

Rebecca Ahrens-Nicklas - Children's Hospital of Philadelphia

Elizabeth Bhoj - Children's Hospital of Philadelphia

Award Collaborative Pairs Pilot Project Awards (2020)
Disease General Neurodegeneration
Identifying the Role of Astrocytes in Neuronal Synapse Loss and Repair in Neurodegenerative Disease
Investigators

Nicola Allen, PhD - Salk Institute for Biological Studies

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease Alzheimer’s Disease, General Neurodegeneration
Illuminating Organelle Dynamics in Development and Neurodegeneration
Investigators

Sarah Cohen - University of North Carolina at Chapel Hill

Mohanish Deshmukh - University of North Carolina at Chapel Hill

Award Collaborative Pairs Pilot Project Awards (2020)
Disease Alzheimer’s Disease, General Neurodegeneration
In Vivo CRISPR Screens to Uncover Regulators of Neurodegeneration
Investigators

Alejandro Chavez - Columbia University

Serge Przedborski - Columbia University

Award Collaborative Pairs Pilot Project Awards (2020)
Disease Spinocerebellar ataxia
In Vivo Forward Genetic Screens by CRISPR for Neurodegeneration Modifiers
Investigators

Yang Hu - Stanford University

Stanley Qi - Stanford University

Award Collaborative Pairs Pilot Project Awards (2020)
Disease General Neurodegeneration
Investigating Mechanisms of Tau-Mediated Neurodegeneration in the Human Brain
Investigators

Inma Cobos, MD, PhD - Stanford University

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease Alzheimer’s Disease, General Neurodegeneration
Investigation of Nuclear Pore Complex Alterations in ALS/FTD
Investigators

Gene Yeo, PhD - University of California, San Diego (Lead PI)

Jeffrey D. Rothstein, MD, PhD - Johns Hopkins University (Clinical PI)

Award Collaborative Science Awards (2019-2021)
Disease ALS, FTD
Lipid Dynamics and Mitochondrial Metabolism in Neurodegenerative Disease
Investigators

Pietro De Camilli - Yale University and HHMI

Hongying Shen - Yale University

Award Collaborative Pairs Pilot Project Awards (2020)
Disease General Neurodegeneration
Longitudinal Full-length, Single Molecule RNA Analysis in Neurodegenerative
Investigators

Robert Spitale - University of California, Irvine

Leslie Thompson - University of California, Irvine

Award Collaborative Pairs Pilot Project Awards (2020)
Disease Huntington’s Disease
Mapping Cellular Networks for Microbiome Contributions to Neurodegeneration
Investigators

Elaine Hsiao, PhD - University of California, Los Angeles

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease General Neurodegeneration
Mechanisms of Blood-Brain Barrier Transporter Regulation: New Avenues for Understanding and Treating Neurodegenerative Disorders
Investigators

Ethan Lippmann, PhD - Vanderbilt University

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease General Neurodegeneration
Membrane Damage and Repair in Neurodegeneration
Investigators

Jeremy Carlton - King's College London

Adrian Isaacs - University College London

Award Collaborative Pairs Pilot Project Awards (2020)
Disease General Neurodegeneration
Molecular Convergence Between Genes and Aging in Neurodegeneration
Investigators

Alessandro Ori - Leibniz Institute on Aging - Fritz Lipmann Institute

Michael Ward - National Institutes of Health

Award Collaborative Pairs Pilot Project Awards (2020)
Disease General Neurodegeneration
Molecular Dissection of Metabolic Homeostasis Pathways in Neurons
Investigators

Marc Hammarlund - Yale University

Gulcin Pekkurnaz - University of California San Diego

Award Collaborative Pairs Pilot Project Awards (2020)
Disease General Neurodegeneration
Molecular Mechanisms of the Central Regulator of TREM2 Dysfunction
Investigators

Celeste Karch, PhD - Washington University in St. Louis (Lead PI)

Gregory Day, MD - Mayo Clinic, Florida (Clinical PI)

Carlos Cruchaga, PhD - Washington University in St. Louis

Oscar Harari, PhD - Washington University in St. Louis

Award Collaborative Science Awards (2019-2021)
Disease Alzheimer’s Disease
Neurolipid Atlas
Investigators

Martin Giera - Leiden University Medical Center

Rik van der Kant - Vrije Universiteit Amsterdam and Amsterdam University Medical Center

Award Collaborative Pairs Pilot Project Awards (2020)
Disease General Neurodegeneration
Neuron-Derived Extracellular Vesicles for Biomarker Discovery in Neurodegeneration
Investigators

David Walt, PhD - Harvard University (Lead PI)

Alice-Chen Plotkin, MD - University of Pennsylvania (Clinical PI)

George Church, MD - Harvard University

Award Collaborative Science Awards (2019-2021)
Disease Parkinson’s Disease
Neuronal Phenotypes of Impaired Nascent Protein Quality Control
Investigators

Wade Harper - Harvard Medical School

Sichen (Susan) Shao - Harvard Medical School

Award Collaborative Pairs Pilot Project Awards (2020)
Disease ALS, Motor Neuron Degeneration
New Roles of the Proteasome in Preventing Neurodegeneration
Investigators

Esteban O. Mazzoni - New York University

Christine Vogel - New York University

Award Collaborative Pairs Pilot Project Awards (2020)
Disease ALS
Next Generation Neuropathology: Proximity-Proteomics of Proteinopathies
Investigators

Melissa E. Murray - Mayo Clinic Florida

Wilfried Rossoll - Mayo Clinic Florida

Award Collaborative Pairs Pilot Project Awards (2020)
Disease General Neurodegeneration
Non-Canonical Pathways Towards Rescue from Neurodegenerative States
Investigators

Viviana Gradinaru, PhD - California Institute of Technology

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease General Neurodegeneration
Probing Parkinson’s Disease with Induced Human Microcircuits on CMOS Chips
Investigators

Patrik Verstreken, PhD - VIB-KU Leuven (Lead PI)

Wim Vandenberghe, MD, PhD - KU Leuven (Clinical PI)

Dries Braeken, PhD - imec Leuven

Birgitt Schuele, MD - Stanford University

Award Collaborative Science Awards (2019-2021)
Disease Parkinson’s Disease
Profiling and Defining Parkinson’s Disease
Investigators

Ernest Arenas, MD, PhD - Karolinska Institutet (Lead PI)

Per Svenningsson, MD, PhD - Karolinska Institutet (Clinical PI)

Sten Linnarsson, PhD - Karolinska Institutet

Mats Nilsson, PhD - Stockholm University

Award Collaborative Science Awards (2019-2021)
Disease Parkinson’s Disease
Promoting Neuronal Cell Death to Mitigate Widespread Neurodegeneration
Investigators

David Simon - Weill Cornell Medicine

Trent Watkins - Baylor College of Medicine

Award Collaborative Pairs Pilot Project Awards (2020)
Disease General Neurodegeneration
Regulation of mRNA and RNP Granules by VCP in Motor Neuron Degeneration
Investigators

Stephanie Moon - University of Michigan

Nils Walter - University of Michigan

Award Collaborative Pairs Pilot Project Awards (2020)
Disease ALS, FTD
Retrotransposon Reactivation in Neurodegenerative Disease
Investigators

Molly Gale Hammell, PhD - Cold Spring Harbor Laboratory

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease ALS, FTD
Role of Dysfunctional Astrocyte-Neuron Signaling in Parkinson’s Disease
Investigators

Cagla Eroglu, PhD - Duke University (Lead PI)

Nicole Calakos, MD, PhD - Duke University (Clinical PI)

Albert La Spada, MD, PhD - Duke University

Award Collaborative Science Awards (2019-2021)
Disease Parkinson’s Disease
Role of White Matter and Cerebrovascular Aging in Neurodegeneration
Investigators

Ozgun Gokce - Institute for Stroke and Dementia Research

Mikael Simons - Technical University Munich and German Center for Neurodegenerative Diseases

Award Collaborative Pairs Pilot Project Awards (2020)
Disease Aging
Spatial Analysis of Aberrant RNA Isoforms in ALS Neuromuscular Organoids
Investigators

Mina Gouti - Max Delbrück Center for Molecular Medicine in the Helmholtz Association

Nikolaus Rajewsky - Max Delbrück Center for Molecular Medicine in the Helmholtz Association

Award Collaborative Pairs Pilot Project Awards (2020)
Disease ALS
Synapse-Microglia Signaling Mechanisms for Proteostasis
Investigators

Takanari Inoue - Johns Hopkins University

Shigeki Watanabe - Johns Hopkins University

Award Collaborative Pairs Pilot Project Awards (2020)
Disease General Neurodegeneration
Targeting Shared Mechanisms in Neurodegenerative and Metabolic Disease
Investigators

Florian T. Merkle, PhD - University of Cambridge

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease Alzheimer’s Disease, General Neurodegeneration, Parkinson’s Disease
The Innate Immune System in Neurodegeneration
Investigators

Ivan Marazzi, PhD - Icahn School of Medicine at Mt. Sinai, New York

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease General Neurodegeneration
The Mitochondrial RNA Structurome as Mediator of Neurological Disease
Investigators

Antoni Barrientos - University of Miami Health System

Silvia Rouskin - Whitehead Institute for Biomedical Research

Award Collaborative Pairs Pilot Project Awards (2020)
Disease General Neurodegeneration
The Physical Biology of Neurodegeneration
Investigators

Liam Holt - New York University School of Medicine

Hemali Phatnani - New York Genome Center

Award Collaborative Pairs Pilot Project Awards (2020)
Disease ALS
The Role of Pink1/Parkin in the Intestinal Epithelium
Investigators

Ming Guo, MD, PhD - University of California, Los Angeles

Elizabeth J. Videlock, MD, PhD - University of California, Los Angeles

Award Collaborative Pairs Pilot Project Awards (2020)
Disease Parkinson’s Disease
The Structural Basis of Protein Pathology in Tauopathy
Investigators

Marc Diamond, MD - UT Southwestern Medical Center (Lead PI)

Charles White, MD - UT Southwestern Medical Center (Clinical PI)

Lukasz Joachimiak, PhD - UT Southwestern Medical Center

Award Collaborative Science Awards (2019-2021)
Disease Alzheimer’s Disease, FTD
Understanding Neuronal Vulnerability to Degeneration in Parkinson’s Disease
Investigators

Maria Soledad Esposito - Centro Atomico Bariloche - Consejo Nacional de Investigaciones Cientificas y Tecnicas

Ignacio E. Schor - Universidad de Buenos Aires - Consejo Nacional de Investigaciones Científicas y Técnicas

Award Collaborative Pairs Pilot Project Awards (2020)
Disease Parkinson’s Disease
Using Antisense Oligonucleotides to Increase mRNA Translation
Investigators

Sergej Djuranovic - Washington University School of Medicine in St. Louis

Timothy Miller - Washington University School of Medicine in St. Louis

Award Collaborative Pairs Pilot Project Awards (2020)
Disease ALS, FTD
Using Computer Vision to Annotate Cryo-Electron Tomograms of Neurons
Investigators

Wah Chiu - Stanford University

Serena Yeung - Stanford University

Award Collaborative Pairs Pilot Project Awards (2020)
Disease General Neurodegeneration, Huntington’s Disease
Viral-Like Mechanisms of Intercellular Communication in the Pathology of Neurodegeneration
Investigators

Jason Shepherd, PhD - The University of Utah

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease Alzheimer’s Disease

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